diff --git a/drivers/iio/chemical/scd4x.c b/drivers/iio/chemical/scd4x.c
index 52cad54e8572..e1f2c76d2275 100644
--- a/drivers/iio/chemical/scd4x.c
+++ b/drivers/iio/chemical/scd4x.c
@@ -585,7 +585,7 @@ static const struct iio_chan_spec scd4x_channels[] = {
 			.sign = 'u',
 			.realbits = 16,
 			.storagebits = 16,
-			.endianness = IIO_BE,
+			.endianness = IIO_CPU,
 		},
 	},
 	{
@@ -600,7 +600,7 @@ static const struct iio_chan_spec scd4x_channels[] = {
 			.sign = 'u',
 			.realbits = 16,
 			.storagebits = 16,
-			.endianness = IIO_BE,
+			.endianness = IIO_CPU,
 		},
 	},
 	{
@@ -613,7 +613,7 @@ static const struct iio_chan_spec scd4x_channels[] = {
 			.sign = 'u',
 			.realbits = 16,
 			.storagebits = 16,
-			.endianness = IIO_BE,
+			.endianness = IIO_CPU,
 		},
 	},
 };